Belissima is an injectable collagen stimulator made from PLLA (poly-L-lactic acid) microspheres, a biocompatible and biodegradable polymer that has been in clinical use for more than two decades. Each vial contains 365 mg of PLLA and is prepared to 5 ml before injection into the subcutaneous layer.
The single active is poly-L-lactic acid in microsphere form, referred to by the maker as PLLA MS. One vial holds 365 mg, and the finished preparation is 5 ml. It is placed beneath the skin in the subcutaneous plane.
Before use, the powder is reconstituted with water for injection (WFI) together with lidocaine. The prepared suspension is then placed in the subcutaneous plane by the practitioner.
Once injected, the PLLA microspheres take up water and act on fibroblasts, the cells responsible for producing collagen. Over the following period, new collagen forms around the particles, while the PLLA itself is slowly absorbed by the body. The effect therefore builds gradually rather than appearing as an immediate volume change, which is the key difference from hyaluronic acid gels.
Collagen stimulators of this type are often discussed for the temple region; our article on temple hollowing gives background.
How much PLLA is in a vial? 365 mg, prepared to a 5 ml volume.
What is it mixed with? Water for injection and lidocaine.
Which layer is it injected into? The subcutaneous layer.
Supplied for clinical use. Lushfills supplies this product to licensed professionals; it should only be administered by a suitably qualified practitioner.
We typically process and ship orders within 1 week, with shipping costs calculated at checkout based on your location and selected method. Free shipping is available for orders over $50, depending on the promotion. Once your order ships, you will receive a confirmation email with a tracking number to monitor your packageβs status. Standard shipping usually takes 5-7 business days, while express options are available for faster delivery. If you need to change your shipping address after placing an order, please contact us as soon as possible. In case of lost or stolen packages, we recommend reaching out to the carrier first, but our support team is happy to assist. For returns, we accept items within 1 week, provided they are unused and in their original packaging. Refunds are processed within 3-5 business days after we receive and inspect the returned item. Exchanges are also available if you need a different size or variant of a product. If you have any questions about shipping or returns, feel free to contact our support team.
Our products are exclusively for use by medical professionals, and are not intended for personal use or self-treatment. The content on this website is for informational purposes only and should not be considered as medical advice or a substitute for professional consultation. Please consult with a qualified healthcare provider for treatment recommendations and safety information.
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